JL

Birth Name:

James L. Manley

Male

Birth Date:

Wed, Nov 30, 1949

Time of Birth:

Unknown (using Noon)

Place of Birth:

Minneapolis, Minnesota, United States

Age:

74

Zodiac Sign:

Sagittarius

Astrology Data:

Sun

8°

Sag

13'

About James L. Manley

James Manley is the Julian Clarence Levi Professor of Life Sciences at Columbia University, where his laboratory studies gene expression in mammalian cells. Manley and colleagues identified and characterized the key factors responsible for polyadenylation of mRNA precursors, and elucidated how this remarkably complex machinery functions in gene regulation, for example during cell growth and differentiation. He has also studied the mechanism and regulation of the process by which introns are removed from mRNA precursors, mRNA splicing. Manley and his coworkers codiscovered the first alternative splicing factor (SR protein), characterized how this and other splicing regulatory proteins function and are themselves regulated, showed how alternative splicing can become deregulated in disease, and with respect to mechanism demonstrated that two spliceosomal small nuclear RNAs by themselves have catalytic activity. Finally, he elucidated unexpected links between these mRNA processing reactions and transcription, DNA damage signaling and maintenance of genomic stability. His work has thus provided considerable insight into the complex mechanisms that are essential for the regulated production of mRNAs in mammalian cells.

Link to Wikipedia biography

External Links:

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Birth Chart and Planetary Positions of James L. Manley

Astrological portrait of James L. Manley

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Astrological aspects and planetary data / tags for James L. Manley: Sun 8 Sagittarius, Moon 14 Aries, Mercury 13 Sagittarius, Venus 25 Capricorn, Mars 18 Virgo, Jupiter 29 Capricorn, Saturn 18 Virgo, Uranus 3 Cancer, Neptune 16 Libra, Pluto 18 Leo, Sun Conjunct Mercury, Mercury Sextile Neptune, Sun Semi Square Venus, Mercury Semi Square Jupiter, Venus Conjunct Jupiter, Mars Conjunct Saturn, Mars Semi Sextile Neptune, Mars Semi Sextile Pluto, Saturn Semi Sextile Neptune, Saturn Semi Sextile Pluto, Uranus Semi Square Pluto, Neptune Sextile Pluto

Categories related to James L. Manley: Living people, November 30 births, Columbia University faculty, 1949 births, Stony Brook University alumni, 21st-century American biologists, Columbia School of Engineering and Applied Science alumni